Neem oil is probably the best product currently available for treating psoriasis. It moisturizes and protects the skin while it helps heal the lesions, scaling and irritation. Experiments and reports from patients with psoriasis have shown taking Neem leaf orally combined with topical treatment with Neem extracts and Neem seed oil appear to be at least as effective as coal tar and cortisone in treating psoriasis.

In a case study a patient with severe psoriasis was given Neem extract (nimbidin) three times a day and the skin treated with nimbidin mixed in coconut oil. The treatments lasted less than three months, stopped the itching, redness and continued to improve the condition of the skin for the duration of treatment. The final result of the treatments was the complete disappearance of the signs of psoriasis. They produced no noticeable side effects. Anecdotal reports indicate that improvements are faster when the areas treated with Neem are also exposed to sunlight.